Year: 2014 Source: Critical Reviews in Food Science and Nutrition.(2014).Accepted author version posted online: 03 Nov 2014. DOI:10.1080/10408398.2013.876960 SIEC No: 20140596

Numerous studies have linked severe stress to the development of major depressive disorder (MDD), and suicidal behaviors. Furthermore, recent preclinical studies from our laboratory and others have demonstrated that in rodents, chronic stress and the stress hormone cortisol has caused oxidative damage to mitochondrial function and membrane lipids in the brain. A growing body of studies suggests the intriguing possibility that regular consumption of certain nutrients may help prevent the onset of mood disorders and suicidal behaviors in vulnerable individuals, or significantly augment the therapeutic effect of available antidepressants. These findings have important implications for the health of both military and civilian populations.