The role of nutrients in protecting mitochondrial function and neurotransmitter signaling: Implications for the treatment of depression, PTSD, and suicidal behaviors.

Numerous studies have linked severe stress to the development of major depressive disorder (MDD), and suicidal behaviors. Furthermore, recent preclinical studies from our laboratory and others have demonstrated that in rodents, chronic stress and the stress hormone cortisol has caused oxidative damage to mitochondrial function and membrane lipids in the brain. A growing body of studies suggests the intriguing possibility that regular consumption of certain nutrients may help prevent the onset of mood disorders and suicidal behaviors in vulnerable individuals, or significantly augment the therapeutic effect of available antidepressants. These findings have important implications for the health of both military and civilian populations.