Association of FKBP5 Polymorphisms With Suicidal Events in the Treatment of Resistant Depression in Adolescents (TORDIA) Study

The relationship between candidate genes & 2 clinical outcomes, symptomatic improvement & the occurrence of suicidal events, was assessed in a sample of treatment-resistant depressed adolescents. Depressed adolescents were genotyped with respect to 21 polymorphisms on 12 genes that have a reported association with depression, treatment response, or suicidal events. No response was observed between any polymorphism & response to treatment. The FKBP5, rs1360780TT, & rs3800373GG genotypes were associated with 18 suicidal events, even after controlling for treatment effects & relevant covariates. These preliminary results are consistent with those from other studies. (39 refs.) JA

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