5HT-2C Receptor Polymorphism in Suicide Victims: Association Studies in German and Slavic Populations

This study tested the association of the polymorphism in the serotonin 2C (5HT-2C) receptor coding region (Cys23Ser) with deaths by suicide. The study was based on 2 independent samples, one German (284 suicide victims versus 297 controls) & the other of Slavic/Croatian ethnicity (118 suicide victims versus 275 controls). No significant differences in allele or genotype frequencies between victims & controls were demonstrated. Results did not provide evidence for the potential involvement of the investigated variants of 5HT-2C receptor in the susceptibility to suicide. (22 refs.) JA