Abstract
5-ht2c Receptor and mao-a Interaction Analysis: no Association With Suicidal Behaviour in Bipolar Patients
De Luca V~~Tharmaligam S~~et al
The authors studied HTR2C haplotypes in suicide attempters. The sample was composed of 306 families with at least one member affected by bipolar disorder. HTR2C variants were analyzed with respect to attempter status & the severity of suicidal behaviour. The X-linked haplotype analysis in relation to suicide attempt did not reveal any significant association. Furthermore, a particular gene-gene interaction for the X-linked serotonergic genes was performed & no association was found among this intergenic haplotype combination & suicidal behaviour in bipolar disorder. (34 refs.) JA