Year: 2008 Source: European Archives of Psychiatry and Clinical Neuroscience, v.258, no.7, (October 2008), p.428-433 SIEC No: 20100862

The authors studied HTR2C haplotypes in suicide attempters. The sample was composed of 306 families with at least one member affected by bipolar disorder. HTR2C variants were analyzed with respect to attempter status & the severity of suicidal behaviour. The X-linked haplotype analysis in relation to suicide attempt did not reveal any significant association. Furthermore, a particular gene-gene interaction for the X-linked serotonergic genes was performed & no association was found among this intergenic haplotype combination & suicidal behaviour in bipolar disorder. (34 refs.) JA