Predictors of Spontaneous and Systematically Assessed Suicidal Adverse Events in the Treatment of SSRI-Resistant Depression in Adolescents (TORDIA) Study
Brent D A~~Emslie G J~~et al
334 depressed adolescents who had not responded to a previous trial with a selective serotonin reuptake inhibitor antidepressant were randomized to a switch to another selective serotonin reuptake inhibitor or venlafaxine, with or without cognitive behaviour therapy. Self-harm events were assessed by spontaneous report from the first 181 participants & by systematic weekly assessment for the last 153 participants. Higher rates of suicide & nonsuicidal self-injury, but not serious adverse events, were detected with systematic monitoring. While there were no main effects of treatment, venlafaxine treatment was associated with a higher rate of self-harm adverse events in those with higher suicide ideation. (39 refs.)
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