Year: 2009 Source: American Journal of Psychiatry, v.166, no.4, (April 2009), p.418-426 SIEC No: 20100238

334 depressed adolescents who had not responded to a previous trial with a selective serotonin reuptake inhibitor antidepressant were randomized to a switch to another selective serotonin reuptake inhibitor or venlafaxine, with or without cognitive behaviour therapy. Self-harm events were assessed by spontaneous report from the first 181 participants & by systematic weekly assessment for the last 153 participants. Higher rates of suicide & nonsuicidal self-injury, but not serious adverse events, were detected with systematic monitoring. While there were no main effects of treatment, venlafaxine treatment was associated with a higher rate of self-harm adverse events in those with higher suicide ideation. (39 refs.)

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