Overview of Existing Research and Information Linking Isotretinoin (Accutane), Depression, Psychosis, and Suicide

Reports of intracranial hypertension, depression, & suicide ideation with Accutane use have prompted an examination of its serious & life-threatening potential. Although the manufacturer has added a warning to the product label, this drug is overprescribed for all forms of acne, including mild & moderate cases that have not been treated with alternative medications with less risk of depression & suicide. This article reviews the research linking Accutane to adverse outcomes, including suicidal behaviours. It is concluded the public must be informed of the proper limited use of Accutance because depression & suicide can occur in patients with no prior history of psychiatric symptoms or suicide attempts. (58 refs.)