Year: 2003 Source: American Journal of Therapeutics, v.10, no.2, (March/April 2003), p.148-159 SIEC No: 20090773

Reports of intracranial hypertension, depression, & suicide ideation with Accutane use have prompted an examination of its serious & life-threatening potential. Although the manufacturer has added a warning to the product label, this drug is overprescribed for all forms of acne, including mild & moderate cases that have not been treated with alternative medications with less risk of depression & suicide. This article reviews the research linking Accutane to adverse outcomes, including suicidal behaviours. It is concluded the public must be informed of the proper limited use of Accutance because depression & suicide can occur in patients with no prior history of psychiatric symptoms or suicide attempts. (58 refs.)