Year: 2008 Source: Journal of Clinical Psychiatry, v.69, no.8, (August 2008), p.1228-1236 SIEC No: 20090562

24 adult men & women diagnosed with major depressive disorder, having a depressive episode with suicidality despite taking an antidepressant, were enrolled in an 8-week double-blind, placebo-controlled study. Subjects were randomly assigned to receive risperidone or placebo while continuing their antidepressant therapy. Clinical efficacy in suicidality, depressive symptoms, & impulsivity were assessed after 4 days, weekly for 4 weeks, then every other week for 4 weeks. Risperidone significantly reduced suicide ideation & the overall effect appeared to be superior to that of the placebo. (58 refs.)