Comorbid Personality Disorder Predicts Suicide After Major Depression: a 10-Year Follow-up

A total of 210 previous participants in multicentre antidepressant drug trials, carried out in a randomized double-blind design, were followed prospectively through a maximum of 10 yeas. Patients with drug or alcohol abuse were excluded. The association between suicide & pretreatment psychopathological profile was analysed using survival statistics. The suicide rate for non-melancholic depressed patients was significantly higher than for melancholic depressed patients. Comorbid personality disorder was independently associated with an increased suicide rate. (27 refs.)