Year: 2006 Source: Neuropsychopharmacology, v.31, no.9, (September 2006), p.1982-1990 SIEC No: 20080579

This study examined whether specific tryptophan hydroxylase-1 haplotypes associate with borderline personality disorder. A case-control design was used. 95 Caucasian women with a diagnosis of borderline personality disorder who attempted suicide at least twice during their lifetime were included. 98 women without psychiatric history formed the control group. While no individual single-nucleotide polymorphisms showed association, several haplotypes associated with the borderline personality group. In particular, one six-single-nucleotide polymorphism was absent from the control group while representing about one-quarter of all haplotypes in the borderline personality disorder group. (55 refs.)