In recent years, incidences of suicide appear to have increased in Pakistan and suicide has become a major public health problem. From available evidence it appears that most suicides occur in young people (single men and married women) under the age of 30 years. Hanging, use of insecticides and firearms are the most common methods and interpersonal relationship problems and domestic issues as the most common reasons for suicide. Mental illness is rarely mentioned. Lack of resources, poorly established primary and mental health services and weak political processes make suicide prevention a formidable challenge in Pakistan. Public and mental health professionals need to work with government and non-governmental organizations to take up this challenge.