Abstract
Altered 5-HT2A and 5-HT4 Postsynaptic Receptors and Their Intracellular Signalling Systems IP3 and cAMP in Brains From Depressed Violent Suicide Victims
Rosel P~~Arranz B~~et al
Serotonin 5-HT2A & 5-HT4 binding parameters & their second messengers 1,4,5-inositol triphosphate & cyclic adenosyl monophosphate were studied in the frontal cortex, hippocampus, caudate nucleus & amygdala of 19 control subjects & 19 antidepressant-free, violent suicide victims. A significantly higher number of 5-HT4 receptors & higher second messenger cAMP concentrations were found in the frontal cortex & caudate nucleus of the depressed suicide victims. Results suggest further studies on suicidality & depression should focus on the functionality of the caudate nucleus. (43 refs.)