Polymorphisms of the Cholecystokinen Gene Promoter Region in Suicide Victims in Japan

The aim of this study was to determine whether any association exists between the genotype of cholecystokinin gene promoter regions & suicidal behaviour. 154 Japanese suicide victims & 328 control subjects were studied. Genotypes & allele frequencies of CCK -45C/T & -196G/A were analyzed using polymerase chain reaction followed by single-strand conformational polymorphism analysis on the genomic DNA. As association between CCK -196G/A polymorphism & suicidal behaviour was found among males; however, a significant association was not discovered in females. (28 refs.)