Year: 2005 Source: Revista Brasileira de Psiquiatria, v.27, no.3, (September 2005), p.172-173 SIEC No: 20060097

Perspectives on the neurobiological basis of suicide have converged in recent years. Observations have shown both serotonin & the prefrontal cortex of the brain influencing suicide. An examination of genes controlling serotonergic neurotransmission has demonstrated association between sequence variants & suicidality. The methodology of microarray analysis of gene expression has become important in the study of complex disorders. More powerful ways of detecting the interactions between multiple genetic loci that are likely to exist in a suicidal behaviour phenotype are possible. (LC) (5 refs)