Selective Serotonin Reuptake Inhibitors in Childhood Depression: Systematic Review of Published Versus Unpublished Data
Whittington C J~~Kendall T~~et al.
A meta-analysis of data from randomized controlled trials that evaluated selective serotonin reuptake inhibitors (SSRIs) versus placebos in participants aged 5-18 years & that were published in a peer-reviewed journal or were unpublished & included in a review by the Committee on Safety Medicines was used to examine the risks & benefits of these drugs. Published data suggest a favourable risk benefit profile for some SSRIs; however addition of unpublished data indicates that risks could outweigh benefits of these drugs to treat depression in children. (LC) (29 refs)