Depression and Suicidal Behavior in Acne Patients Treated With Isotretinoin: a Systematic Review

A systematic literature search for studies reporting primary data on depression & suicidal behaviour in patients treated with isotretinoin for acne vulgaris was performed. 9 studies met the qualifying criteria for this analysis. Rates of depression among isotretinoin users ranged from 1-11% across studies, with similar rates in oral antibiotic control groups. The available data on suicidal behaviour during isotretinoin treatment are insufficient to establish a meaningful causative association. (LC) (53 refs)