Year: 2005 Source: Seminars in Cutaneous Medicine and Surgery, v.24, no.2, (June 2005), p.92-102 SIEC No: 20052087

A systematic literature search for studies reporting primary data on depression & suicidal behaviour in patients treated with isotretinoin for acne vulgaris was performed. 9 studies met the qualifying criteria for this analysis. Rates of depression among isotretinoin users ranged from 1-11% across studies, with similar rates in oral antibiotic control groups. The available data on suicidal behaviour during isotretinoin treatment are insufficient to establish a meaningful causative association. (LC) (53 refs)