Year: 2003 Source: Journal of Neuroscience, v.23, no.5, (24 September 2003), p.8788-8799 SIEC No: 20050344

Inhibition of serotonergic raphe neurons is mediated by somatodendritic 5-HT1A autoreceptors, which may be increased in depressed patients. The authors report an association of the C(-1019)G 5-HT1A promoter polymorphism with major depression & suicide in separate cohorts. (64 refs)