Selective Serotonin Reuptake Inhibitors (SSRIs) and Suicide in Adults: Meta-Analysis of Drug Company Data From Placebo Controlled, Randomised Controlled Trials…

The authors completed a meta-analysis of randomized controlled trials performed by pharmaceutical companies to compare selective serotonin reuptake inhibitors (SSRIs) with placebo, in order to investigate whether SSRIs are associated with an increased risk of suicide related outcomes in adults. They found that increased risk for suicide and self harm caused by SSRIs cannot be ruled out, but larger trials with longer follow-up are required to fully assess the balance of risks & benefits. (24 refs)