Year: 2004 Source: Archives of General Psychiatry, v.61, (July 2004), p.685-693 SIEC No: 20050112

This article examines whether the pathogenesis of teenage suicide is associated with changes in protein kinase C (PKC), using a postmortem brain study. The authors found that PKC activity was statistically significantly decreased in the brains of suicide victims compared with control subjects. Significant decreases in protein levels were found to be associated with decreases in levels of the respective messenger RNAs. (50 refs)