Year: 2003 Source: The Neuroscientist, v.9, no.4, (2003), p.237-242 SIEC No: 20040363

The author discusses findings that show that the most complex alterations in 5-HT2C pre-mRNA editing of the serotonin 2C receptor have been found in brains of depressed suicide victims. In these brains, 5-HT2C receptor isoforms with reduced function are expressed at significantly increased levels, suggesting that the regulation of editing by synaptic serotonin is defective. (21 refs)