Neuropeptide YY1 and Y2 Receptor mRNA Expression in the Prefrontal Cortex of Psychiatric Subjects: Relationship of Y2 Subtype to Suicidal Behavior

In this study, Y1 & Y2 receptor mRNA expression levels were analyzed in the dorsolateral prefrontal cortex of subjects affected with major depression, bipolar disorder, or schizophrenia & compared to normal controls. No significant alterations in Y1 or Y2 mRNA expression levels were observed between the groups. However, the Y2 mRNA expression was elevated in layer IV in subjects with suicide as a cause of death. (28 refs)