Abstract
Substance Abuse Disorder and Major Depression are Associated With the Human 5-HT(1B) Receptor Gene (HTR1B) G861C Polymorphism
Huang Y~~Oquendo M A~~et al
This study was performed in order to test the potential genetic relationships between the 5-HT(1B) receptor & several psychopathologies including pathological aggression, alcoholism & suicide. The findings indicate that substance abuse disorder & major depression are associated with the 5-HT(1B) G861C locus in the patient population, but other psychopathologies such as bipolar disorder, schizophrenia, alcoholism, & suicide attempts were not found to be associated with this polymorphism. (39 refs)