Lower Serum High-Density Lipoprotein Cholesterol (HDL-C) in Major Depression and in Depressed men With Serious Suicidal Attempts: Relationship With Immune-Inflammatory Markers

The aim of this study was to examine whether (i) major depression is accompanied by lower serum HDL-C or by abnormal levels of total cholesterol, triglycerides, low-density lipoprotein-C or vitamin E; (ii) suicidal attempts are related to lower serum HDL-C and (iii) there are significant associations between serum HDL-C and immune/inflammatory markers. It was found that serum HDL-C levels were significantly lower in depressed men who had at some time made serious suicidal attempts than in those without any suicidal behaviour. (47 refs)