Imipramine binding (desipramine- & serotonin-sensitive) was determined in the frontal cortex of suicide victims & nonpsychiatric controls who died due to medical disease or accidents. There were no differences found in Kd or Bmax of imipramine binding between controls & suicides. The Kd & Bmax values of serotonin-sensitive imipramine binding were significantly lower than desipramine-sensitive imipramine binding, both in controls & suicides. There were significant correlations between Kd & Bmax of serotonin-sensitive imipramine binding & desipramine-sensitive imipramine binding in suicides but not in controls. (54 refs)