Year: 2001 Source: Molecular Psychiatry, v.6, no.5, (September 2001), p.540-546 SIEC No: 20020450

We employed quantitative TaqMan PCR to analyze the expression & distribution of both Corticotropin-releasing hormone receptor-1 (CRH-R1) & CRH-R2 in human brain tissue & peripheral organs. Furthermore the expression of CRH receptors was analyzed for the first time in pituitaries of suicide victims by in situ hybridization & quantitative PCR. Both receptors were expressed in high amounts in the brain with the strongest expression in the pituitary. CRH-R1 was the predominant receptor in the brain whilst CRH-R2 was the predominant receptor in peripheral organs. There was a shift in the ratio of CRH-1/R2 in the pituitaries of suicide victims. (38 refs)