Year: 2000 Source: Psychiatry Research, v.97, no.2-3, (December 2000), p.101-106 SIEC No: 20011088

The association of suicidal behaviour in Chinese patients with schizophrenia with a functional polymorphism of the promoter region of the 5-HTT gene (5-HTTLPR) was examined. The 5-HTTLPR genotype was determined by polymerase chain reaction for 76 suicidal & 262 nonsuicidal patients with a diagnosis of schizophrenia. There was no significant genotypic or allelic association of the 5-HTTLPR polymorphism with a history of attempted sucide. From the results of this study, this 5-HTTLPR polymorphism is unlikely to have a major effect on suicidal behaviour in Chinese patients with schizophrenia. (27 refs.)