This report reviews recent findings relative to the risk of suicide in schizophrenia, including data from the Chestnut Lodge longitudinal study of schizophrenia subtypes & symptom domains. Paradoxically, those patients with schizophrenia who are most likely to recover or experience a good outcome are also those at greatest risk for suicide. The reduction of morbidity & mortality in schizophrenia should include depression & suicidality as targets for both psychopharmacological & psychosocial treatment. (90 refs.)