Year: 2000 Source: American Journal of Psychiatry, v.157, no.9, (September 2000), p.1429-1435 SIEC No: 20010251

The efficacy of lithium augmentation in the continuation treatment of unipolar major depressive disorder was examined. 30 patients with a refractory major depressive episode who had responded to acute lithium augmentation during an open 6-week study participated in a randomized, parallel-group, double-blind, placebo-controlled trial of lithium augmentation during continuation treatment. Relapses, including one suicide, occurred in 7 of the 15 patients who received placebo in addition to antidepressants. None of the 14 patients who received lithium augmentation with antidepressants suffered a relapse during the double-blind phase of the study. (44 refs.)