Year: 1997 Source: American Journal of Psychiatry, v.154, no.10, (October 1997), p.1451-1453 SIEC No: 19980670

51 inpatients with major depression, with or without a history of suicidal acts, were genotyped for a biallelic polymorphism at the tyrptophan hydroxylase locus. The less common tryptophan hydroxylase U allele occurred with greater frequency in patients who had attempted suicide. Analysis confirmed an association between tryptophan hydroxylase genotype & lifetime history of suicide attempts. Serotonergic-system-related genes may influence the risk of suicide in persons with major depression.