Year: 1997 Source: Annals of the New York Academy of Sciences, v.836, (December 29, 1997), p.106-134 SIEC No: 19980438

This study discusses serotonin (5-HT) disturbances in suicide attempters/victims as well as dysregulation in the hypothalamic-pituitary-adrenal (HPA) axis and relates the two together. Their review of animal studies found that chronic unpredictable stress increases corticosteroid levels in rats, and changes specific 5-HT receptors. They also found that chronic antidepressant administration can prevent these 5-HT receptor changes as well as reverse the overactivity in the HPA axis. (122 refs.)