Abstract
3H Imipramine Binding in Brain Samples From Depressed Suicides and Controls: 5-HT Uptake Sites Compared With Sites Defined by Desmethylimipramine
Lawrence K M~~Kanagasundaram M~~et al
Using desmethylimipramine defined & Na+ dependent 3H imipramine binding, both 5-HT uptake sites & sites unrelated to 5-HT uptake were examined in frontal cortex, putamen & substantia nigra of suicides with a firm retrospective diagnosis of depression & matched controls. No differences were seen between antidepressant-free suicides & controls, although 3H imipramine binding sites were significantly lower in putamen of non-violent suicides.