Increased Levels of a Mitochondrial DNA Deletion in the Brain of Patients With Bipolar Disorder
Kato T~~Stine O C~~et al
The possible pathophysiological significance of mitochondrial DNA deletions in bipolar disorder were studied by examining the concentration of the 4977-base-pair deletion in mitrochondrial DNA in the autopsied brains of 7 patients with bipolar disorder, 9 suicide victims & 9 controls. When the bipolar & suicide groups were combined they tended to have higher levels of the deletion. The ratio of deleted to wild-type mitochondrial DNA was significantly higher in bipolar patients than in controls.