Referring to the Henry (1997) and the Hotopf & Lewis (1997) correspondence, this author argues that factors promoting fatal overdose with antidepressants may be non-specific, such as inappropriate prescribing, inadequate dosage, or inadequate monitoring of antidepressant prescriptions. Targeting these factors, which may reduce the overall effectiveness (of any antidepressant), via educational & training programs may be more productive than “switching” from one anti-depressant class to another.