Platelet 5-HT Uptake Sites, Labelled With 3H Paroxetine, in Controls and Depressed Patients Before and After Treatment With Fluoxetine or Lofepramine

Platelet 3H paroxetine was measured in 73 depressed patients & 64 healthy volunteers. No differences were found in Bmax or Kd. None of the subgroups differed significantly from controls. 40 of the depressed subjects were retested after 6 weeks’ treatment with fluoxetine or lofepramine. Treatment was not associated with any change in Bmax but an increase in Kd was noted. Neither pre- nor post-treatment platelet binding parameters appeared to relate to clinical response to treatment.