A retrospective study of 30 Huntington’s disease families (110 patients: 75 alive & 35 dead) showed the minimum lifetime prevalence of depression to be 39% in the prodrome & the diagnosed disease phase of the illness. The frequency of symptomatic schizophrenias was found to be about 9% & significant personality changes were found in 72% of the sample. There were 4 suicides, all of which were preceded by a history of depression. There were also 12 suicide attempts & 1 case of self-mutilation.