Year: 1995 Source: American Journal of Human Genetics, v.56, no.1, (January 1995), p.332-335 SIEC No: 19950196

A pathogenic double-mutation was detected in families with early-onset alzheimer disease. This article reports on APP 670/671 mutation analysis for presymptomatic testing of family at risk of inheriting the disease. Of 3 members tested for the mutation, the one shown to be a carrier reacted with depression & suicidal thoughts. It is considered essential that those being tested receive extensive information & consultation before & after. A case where genetic counselling led to suicide is noted.