An investigation of the morbidity & mortality associated with self-poisoning with different drug classes is reported in this article. Data from 1969 admissions to a toxicology centre were examined including 83 drug-related deaths. Most frequently ingested substances: benzodiazepines, alcohol, paracetamol, antidepressants, neuroleptics, & anticonvulsants. Conclusions: use antidepressants that are safer in overdose; discourage use of antidepressants, barbituates or chloral hydrate as sedatives.