Comparison of Frequencies of Suicidal Tendencies Among Patients Receiving Fluoxetine, Lofepramine, Mianserin, or Trazodone

To evaluate whether fluoxetine causes an important increased risk of suicidal behaviour, the frequency of attempted suicide, suicidal ideation, & aggressive behaviour was compared in persons who received fluoxetine, lofepramine, mianserin & trazodone. The frequency of these events in the 90 days after the study drug was started was similar for all user groups. Data show that fluoxetine does not directly cause suicidal behaviour at a substantially higher frequency than the other 3 drugs studied.