In this letter, the authors report on a 44-year-old male who attempted suicide by means of nicotine overdose. An inquiry to Marion Merrell Dow Inc. revealed that 4 other cases of overdose or attempted overdose with Nicoderm had been reported. Only one of these was intentional & none resulted in death. It is suggested that physicians screen each patient’s affective status prior to issuing prescriptions for nicotine patches.