Time Series Analysis of Intervention Effects: Fluoxetine Therapy as a Case Illustration

This paper illustrates the advantages of time series analysis in documenting treatment effects through a case study of a trial of fluoxetine in a 22-year-old depressed, suicidal woman. Data consisted of weekly self-reports of symptomatology over 58 weeks of hospitalization. Intervention analysis carried out after the patient was discharged documented the effectiveness of the medication & the differential timing of response in individual symptoms. (7 refs.)