Year: 1992 Source: Biological Psychiatry, v.32, no.10, (November 15, 1992), p.922-931 SIEC No: 19920989

Benzodiazepine binding sites were studied by autoradiography in several hippocampic layers in brains of drug-free violent suicide victims & matched controls. Kd was increased in suicides, & when brain sections from control subjects were incubated in the bath fluid that had previously served to incubate sections from suicides, Kd was increased in the same way. Results are discussed in terms of possible modulators of benzodiazepine binding sites, mainly tissue GABA & amino acid concentrations.