In this letter to the editor, Pearlman questions how Rothschild & Locke differentiated their findings on fluoxetine-induce akathisia from anxiety-induced agitation. Pearlman takes issue with their views on the relationship between fluoxetine & suicidality, making the point that a sequence of events does not imply a cause & effect relationship. The reply of Drs. Rothschild & Locke follows.