Year: 1992 Source: Synapse, v.10, no.1, (January 1992), p.79-82 SIEC No: 19920194

Antibodies against tyrosine hydroxylase (TH, the rate-limiting enzyme in norepinephrine synthesis) & dopamine hydroxylase (DBH) were used for immunohistochemical staining of human brain locus coeruleus sections, obtained postmortem from suicide victims & matched controls. Mean stain density for TH was significantly lower in the locus coeruleus of suicide victims. There was no difference between suicides & controls in DBH immunoreactivity or in the number of TH immunoreactive cells. (19 Refs.)