Between 1972-88, 145 deaths occurred among 3,126 multiple sclerosis (MS) patients in 2 Canadian clinics. 18 of 119 cases in which the exact cause of death was known were suicides, with another 2 deaths which may have been suicide. The proportion of suicides among MS patients was 7.5 times that for the age-matched general population. The authors note the inconsistencies in classifying suicide as a complication of MS. The relationship between MS, depression & suicide also remains uncertain.