Year: 1991 Source: Psychiatry Research, v.37, no.3, (June 1991), p.271-279 SIEC No: 19911010

Studied the relationship between increased serotonin (5HT) receptor sensitivity & human aggression. A low, oral dose of meta-chlorophenylpiperazine (MCPP) was administered to 42 patients, including 11 who had attempted suicide (inward aggression). Results showed that patients with a history of suicide attempts did not have significantly greater MCPP-induced cortisol or prolactin release than did normal controls & that MCPP induced hormone release is unrelated to measures of aggression. (40 refs)