This article describes the relationship between Multiple Sclerosis (MS) & suicide. The suicide rate is 13-14 times higher in MS patients than in the general population. This study is an interim report on 18 suicides in a series of 46. Interviews were conducted with family members or spouses of the suicide victims. Most suicide victims had significant losses in functioning, & changes in level of independence, control & coping ability. Most were depressed & withdrawn. (VM)