Lack of Specificity of Reduced Platelet Imipramine Binding in Different Psychiatric Conditions

This study compares 3-H-imipramine binding in 10 patients with major depression, to that in 29 health volunteers, 13 patients with panic disorders, 9 patients with bulimia, 9 suicide attempters, & 6 schizophrenic patients. The authors found a significant reduction of the maximum binding capacity in all groups of patients as compared with healthy controls. They conclude that this suggests a possible common denominator: serotonin. (VM)