Affective Disorders and Aggression Disorders: Evidence for a Common Biological Mechanism

Van Praag reviews recent biochemical research & concludes that most studies have found a correlation between suicidal behavior & low levels of CSF 5-HIAA; that evidence of a connection between violence & the attempt is equivocal and that the theory that low CSF 5-HIAA levels predict increased suicide risk has not yet been confirmed. The author believes disturbances in serotonergic regulation can give rise to both mood & aggression disorders. 100 Ref. (NBB)