Impaired Metabolism of Methylphenobarbital After a Combined Drug Overdose: Treatment by Resin Hemoperfusion

A 38-year old woman who by history ingested 13 g methylphenobarbital, alcohol, & 6 g acetaminophen became comatose slowly over 4 days. On the eighth day after ingestion she was treated because of protracted coma with Amberline Xad-4 Resin hemoperfusion, which led to transient clinical improvement. When supportive patient management fails to produce a satisfactory clinical course in a Methylphenobarbital-Intoxicated patient, hemoperfusion could be a useful adjunct to therapy. 15 Refs. (LH)