Year: 1986 Source: Carrier Foundation Letter, no.116, (May 1986), p.1-3 SIEC No: 19861037

Psychotic depression appears to be a distinct illness having a different clinical presentation, history, & prognosis from non-psychotic depression. Both the higher treatent response to the combination of antidepressants & antipsychotics, compared to tricyclic antidepressants used alone, & findings of possible dopaminergic overactivity & noradrenergic underactivity lead to the assumption that the neurobiology of this disorder is distinct as well. Early recognition is critically important.