Year: 1980 Source: American Journal of Psychiatry, v.137, no.11, (November 1980), p.1414-1415 SIEC No: 19842709

The authors describe 3 patients who attempted to commit suicide by ingesting overdoses of lorazepam, an intermediate – acting benzodiazepine that, unlike diazepam, has no active metabolites. All 3 were clinically well within 24-30 hours of ingestion, although high lorazepam concentrations persisted. The authors point out that the elimination half-life of lorazepam after extremely high doses have been ingested is approximately the same as that found after ingestion of usual therapeutic doses.